Dipeptides

L-α-dipeptides (dipeptides) tsis tau kawm ze li ntau tau muaj cov proteins thiab amino acids.Thawj qhov kev tshawb fawb tau ua tiav ntawm L-aspartyl-L-phenylalanine methylester (aspartame) thiab Ala-Gln (Lalanyl-L-glutamine) vim tias lawv tau siv hauv cov khoom lag luam nrov.Ntxiv rau qhov tseeb no, lwm qhov laj thawj ntau cov dipeptides tsis tau kawm kom ntxaws yog vim tias cov khoom siv dipeptide tsis muaj cov txheej txheem tsim khoom zoo, txawm hais tias muaj ntau yam tshuaj thiab chemoenzymatic txoj kev tau tshaj tawm.

Carnosine - piv txwv ntawm dipeptide
Txog thaum tsis ntev los no, cov txheej txheem tshiab tau tsim los rau dipeptide synthesis uas cov dipeptides raug tsim los ntawm cov txheej txheem fermentative.Qee cov dipeptides muaj qhov tshwj xeeb ntawm lub cev muaj peev xwm, tso cai rau lawv tuaj yeem ua kom nrawm dua cov ntawv thov dipeptide hauv ntau qhov kev tshawb fawb tshawb fawb.L-α-dipeptides yog tsim los ntawm cov peptide tsis yooj yim tshaj plaws ntawm ob cov amino acids, tab sis lawv tsis tau yooj yim muaj feem ntau vim qhov exiguity ntawm cov nqi tsim khoom.Dipeptides, txawm li cas los xij, muaj lub luag haujlwm nthuav dav, thiab cov ntaub ntawv tshawb fawb nyob ib puag ncig lawv nce ntxiv.Qhov no yoojyim rau ntau tus kws tshawb fawb nrog tus nqi ntawm kev tsim cov txheej txheem ntau dua thiab raug nqi ntawm dipeptide ntau lawm.Thaum daim teb no tau kawm ntau dua, nws cia siab tias peb tuaj yeem kawm ntau ntxiv txog qhov muaj txiaj ntsig peptides tiag tiag.

Dipeptides muaj ob txoj haujlwm yooj yim, uas yog:
1. Ib qho derivative ntawm cov amino acids
2. Lub dipeptide nws tus kheej

Raws li ib tug derivative ntawm cov amino acids, dipeptides, nrog rau lawv cov amino acids muaj ntau yam physiochemical zog, tab sis lawv feem ntau qhia tib yam physiological teebmeem.Qhov no yog vim hais tias dipeptides tau degraded rau hauv cov amino acids cais nyob rau hauv cov kab mob nyob, uas muaj ntau yam physicochemical zog.Piv txwv li, L-glutamine (Gln) yog tshav kub-labile, thaum Ala-Gin (L-alanyl-L-glutamine) yog tshav kub kub.

Tshuaj synthesis ntawm dipeptides tshwm sim raws li nram no:
1. Txhua pawg ua haujlwm dipeptide raug tiv thaiv (tshwj tsis yog cov uas koom nrog tsim cov peptide daim ntawv cog lus ntawm cov amino acids).
2. Cov tshuaj tiv thaiv amino acid ntawm pawg dawb carboxyl yog qhib.
3. Cov activated amino acid reacts nrog rau lwm cov amino acid tiv thaiv.
4. Cov pab pawg tiv thaiv uas muaj nyob rau hauv dipeptide raug tshem tawm.